Tuesday, February 23, 2010

Package leaflet warnings - Levitra/Vivanza (Vardenafil)

Do not take Levitra

* If you are allergic (hypersensitive) to vardenafil or any of the other ingredients of Levitra. See the ingredients in section 6. Signs of an allergic reaction include a rash, itching, swollen face or lips and shortness of breath.

* If you are taking medicines containing nitrates, such as glycerol trinitrate for angina, or nitric oxide donors, such as amyl nitrite. Taking these medicines with Levitra could seriously affect your blood pressure.

* If you are taking ritonavir or indinavir, medicines for HIV.

* If you are over 75 years of age and are taking ketoconazole or itraconazole, anti-fungal medicines

* If you have a severe heart or liver problem

* If you are having kidney dialysis

* If you have recently had a stroke or heart attack

* If you have or have had low blood pressure

* If your family has a history of degenerative eye diseases (such as retinitis pigmentosa)

* If you have ever had a condition involving loss of vision due to damage to the optic nerve from insufficient blood supply known as non-arteritic ischemic optic neuropathy (NAION)

Take special care with Levitra

* If you have heart trouble. It may be risky for you to have sex

* If you suffer from irregular heart beat (cardiac arrythmia) or inherited heart diseases affecting your electrocardiogram

* If you have a physical condition affecting the shape of the penis. This includes conditions called angulation, Peyronie’s disease and cavernosal fibrosis

* If you have an illness that can cause erections which won’t go away (priapism). These include sickle cell disease, multiple myeloma and leukaemia

* If you have stomach ulcers (also called gastric or peptic ulcers)

* If you have a bleeding disorder (such as haemophilia)

* If you are using any other treatments for erection difficulties

* If you experience sudden decrease or loss of vision, stop taking Levitra and contact your doctor immediately


Extracted from European Medicines Agency package leaflet information. (EMEA/H/C/475, August 2008)

Package leaflet warnings - Cialis (Tadalafil)

Do not take CIALIS

* If you are allergic (hypersensitive) to tadalafil or any of the other ingredients of CIALIS.

* If you are taking any form of organic nitrate or nitric oxide donors such as amyl nitrite. This is a group of medicines (“nitrates”) used in the treatment of angina pectoris (“chest pain”). CIALIS has been shown to increase the effects of these medicines. If you are taking any form of nitrate or are unsure tell your doctor.

* If you have serious heart disease or have had a recent heart attack.

* If you have had a recent stroke.

* If you have low blood pressure or uncontrolled high blood pressure.

* If you have ever had loss of vision because of non-arteritic anterior ischemic optic neuropathy (NAION), a condition sometimes described as “stroke of the eye”.

Take special care with CIALIS
Be aware that sexual activity carries a possible risk to patients with heart disease because it puts an extra strain on your heart. If you have a heart problem you should tell your doctor.

The following are reasons why CIALIS may also not be suitable for you. If any of them apply to you, talk to your doctor before you take the medicine:

* You have sickle cell anaemia (an abnormality of red blood cells), multiple myeloma (cancer of the bone marrow), leukaemia (cancer of the blood cells) or any deformation of your penis.

* You have a serious liver problem.

* You have a severe kidney problem.

It is not known if CIALIS is effective in patients who have undergone pelvic surgery or radical non-nerve-sparing prostatectomy.

If you experience sudden decrease or loss of vision, stop taking CIALIS and contact your doctor immediately.


Extracted from European Medicines Agency package leaflet information. (EMEA/H/C/436, November 2008)

Package leaflet warnings - Viagra (Sildenafil)

Do not take VIAGRA

* If you are taking medicines called nitrates, as the combination may cause a potentially dangerous decrease in your blood pressure. Tell your doctor if you are taking any of these medicines which are often given for relief of angina pectoris (or “chest pain”). If you are not certain, ask your doctor or pharmacist.

* If you are using any of the drugs known as nitric oxide donors such as amyl nitrite (“poppers”), as the combination may also lead to a potentially dangerous decrease in your blood pressure.

* If you are allergic (hypersensitive) to sildenafil or any of the other ingredients of VIAGRA.

* If you have a severe heart or liver problem.

* If you have recently had a stroke or a heart attack, or if you have low blood pressure.

* If you have certain rare inherited eye diseases (such as retinitis pigmentosa).

* If you have ever had loss of vision due to non-arteritic anterior ischaemic optic neuropathy (NAION).

Take special care with VIAGRA
Tell your doctor

* If you have sickle cell anaemia (an abnormality of red blood cells), leukaemia (cancer of blood cells), multiple myeloma (cancer of bone marrow).

* If you have a deformity of your penis or Peyronie’s Disease.

* If you have problems with your heart. Your doctor should in that case carefully check whether your heart can take the additional strain of having sex.

* If you currently have a stomach ulcer, or a bleeding problems (such as haemophilia).

* If you experience sudden decrease or loss of vision, stop taking VIAGRA and contact your doctor immediately.


Extracted from European Medicines Agency package leaflet information. (EMEA/H/C/202, November 2008)

Monday, February 22, 2010

Side effects – why PDE5-Is may not be for you

Let's get the easy part out of the way first! I am referring to 5-phosphodiesterase inhibitors otherwise known as PDE5-Is.

Still doesn't help?

Perhaps it will mean something when I refer to them under their more familiar names:

Marketing name Pharmaceutical name Company

Viagra Sildenafil Pfizer

Cialis Tadalafil Eli Lilly

Levitra/Vivanza Vardenafil Bayer/GSK


I am sure that even if you have never once taken either of the above you undoubtedly have heard of them from a friend, or from Hollywood or from emails in your inbox!

However, they are not necessarily the panacea you are looking for, especially if you have heart problems. I strongly advise everyone to read the warnings on the three principal medications. This is particularly the case if you have or intend to acquire them from non-regular sources i.e. not from your usual doctor/physician.

Friday, February 19, 2010

Some facts – boring but necessary

Erectile dysfunction (ED) affects over 150 million worldwide and roughly 30 million in the US and 20 million in the European Union. The UN estimates that incidence will double by 2025!

Vascular disease is probably the most common cause of ED and is almost always associated with it.

Cardiovascular disease is the most common of all the causes, with its risk factors of:
Smoking
Hypertension
Hyperlipidaemia
Diabetes
Therapeutic drugs side-effects

Why have I established this blog?

The principal object of this blog is to explore up-and-coming alternative and innovative treatments for erectile dysfunction (ED) which avoid medication with potentially harmful side effects as well as solutions for individuals who cannot, for medical reasons, take Viagra, Cialis, Levitra etc.

The blog will also highlight new and up-and-coming technologies with a potential impact in the field of urology and andrology.